Curcumin attenuated paracetamol overdose induced hepatitis

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Effects of Curcumin Attenuated Hepatitis in Mice with Paracetamol Overdose

Background: N-acetyl-p-aminophenol (APAP) or paracetamol overdose causes increasing of toxic metabolites, which disrupting hepatocyte function, and liver injury occurs. Curcumin has been used for treatment of inflammatory conditions such as hepatitis. Therefore, this study aims to determine effects of curcumin attenuate hepatitis in mice with APAP overdose. Methods: Male mice (25-30 gram) were ...

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Interventions for paracetamol (acetaminophen) overdose.

BACKGROUND Paracetamol (acetaminophen) is the most widely used non-prescription analgesic in the world. Paracetamol is commonly taken in overdose either deliberately or unintentionally. In high-income countries, paracetamol toxicity is a common cause of acute liver injury. There are various interventions to treat paracetamol poisoning, depending on the clinical status of the person. These inter...

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ژورنال

عنوان ژورنال: World Journal of Gastroenterology

سال: 2013

ISSN: 1007-9327

DOI: 10.3748/wjg.v19.i12.1962